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Communication | Regular issue | Vol 22, No. 8, 1984, pp.1697-1700
Published online, 1st January, 1970
DOI: 10.3987/R-1984-08-1697
Facile Synthesis of Thiazolo[4,5-b]- and Thieno[3,2-b]pyridine Derivatives by a Novel Pyridine Cyclization Reaction via Enamine Intermediates

Isao Hayakawa* and Yoshiaki Tanaka

*Exploratory Research Laboratories I, Daiichi Pharmaceutical Co., Ltd., 16-13, Kitakasai 1-chome, Edsogawa-ku, Tokyo 134, Japan


Thiazolo[4,5-b]- and thieno[3,2-b]pyridine-6-carboxylic acid derivatives were synthesized by formation of the thiazole or the thiophene ring bearing o-amino-β-ketoester moiety, followed by a novel pyridine cyclization reaction with DMF-dimethylacetal .