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Communication | Regular issue | Vol 22, No. 7, 1984, pp.1489-1492
Published online, 1st January, 1970
DOI: 10.3987/R-1984-07-1489
A Simple Route to Spiroketals via Alkylation of Dihydropyran

Roger Amouroux*

*Laboratoire de Chimie Organique Physique et Synthétique, Associe au CNRS, Université Claude Bernard, Lyon 1, 43, Bd du 11 Novembre 1918, 69622 Villeurbanne Cedex, France

Abstract

3,4-Dihydro-2H-pyran was alkylated, via its 2-lithio derivative, with several O-protected β- or γ-iodo alcohols in excellent yields. Acidic treatment of the resultant 2-substituted dihydropyrans produced both the deprotection of the hydroxyl group and the cyclization to spiroketals.