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Communication | Regular issue | Vol 22, No. 6, 1984, pp.1343-1345
Published online, 1st January, 1970
DOI: 10.3987/R-1984-06-1343
Biotransformation of a Tetrahydroprotoberberine N-Metho Salt to a Spirobenzyisoquinoline Accompanying N-Methyl Group Transfer to O-Methyl Group by Callus Cultures of Corydalis Species

Kinuko Iwasa,* Akiko Tomii, Narao Takao, Toshimasa Ishida, and Masatoshi Inoue

*Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan


The Structure and stereochemistry of base C, a 13-hydroxytetrahydroprotoberberine metabolite in cell cultures, have been determined by X-ray analysis. Thereby the biotransformation of a tetrahydroprotoberberine N-metho salt to a spirobenzylisoquinoline , involving a migration of the N-methyl group to the O-methyl group was first demonstrated.