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Communication | Regular issue | Vol 22, No. 6, 1984, pp.1315-1318
Published online, 1st January, 1970
DOI: 10.3987/R-1984-06-1315
A Convenient Synthetic Method of 1-Acyl-2-aryl-3,3-dimethylindole Involving Isolable Diastereomeric Atropisomers

Takeo Kitamura,* Toshitaka Koga, Tanezo Taguchi, and Kazunobu Harano

*Daiichi College of Pharmaceutical Sciences, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-0037


The synthesis of 1-acyl-2-aryl-3,3-dimethylindoline was improved by the reaction of 1-acyl-2-hydroxy-3,3-dimethylindoline with an arene in the presence of BF3·O(C2H5)2 in dioxane, and stable diastereomeric atropisomers were isolated as products when the arene was β-naphthol.