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Report | Regular issue | Vol 22, No. 3, 1984, pp.565-568
Published online, 1st January, 1970
DOI: 10.3987/R-1984-03-0565
Synthesis of Some 2-Deoxy-2-fluoro[18F]hexopyranoses, Potential Diagnostic Imaging Agents

Masao Tada,* Taiju Matsuzawa, Hiroshi Ohrui, Hiroshi Fukada, Tatsuo Ido, Toshihiro Takahashi, Makoto Shinohara, and Kumiko Komatsu

*Research Institute for Tuberculosis and Cancer, Tohoku University, Seiryo-machi, 4-1, Aobaku, Sendai, 980-, Miyagi, Japan

Abstract

2-Deoxy-2-fluoro[18F]-D-galacto-, -D-altro-, and -L-gluco-pyranose have been prepared by the reactions of corresponding glycals with fluorine[18F] gas followed by acidic hydrolysis, respectively. The gas was produced by the 20Ne(d, α) 18F nuclear reaction using the cyclotron. D-Galactopyranose derivative showed markedly diagnostic liver-imaging activity.