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Report | Regular issue | Vol 22, No. 3, 1984, pp.531-535
Published online, 1st January, 1970
DOI: 10.3987/R-1984-03-0531
Oxidation Studies on Beta-Lactam Antibiotics Synthesis of Penam and Cephem Sulfoxides and Sulfones

Ronald G. Micetich,* Rajeshwar Singh, and Samarendra N. Maiti

*Faculty of Pharmacy , University of Alberta, Edmonton, Alberta T6G, 2N8, , Canada


Penicillin and cephalosporin sulfoxides are conveniently prepared by oxidation of the respective penicillin or cephalosporin in methylene chloride using hydrogen peroxide and acetic acid. Replacement of the acetic acid by formic acid produces the respective penicillin and cephalosporin sulfones in high yields.