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Communication | Regular issue | Vol 22, No. 2, 1984, pp.257-260
Published online, 1st January, 1970
DOI: 10.3987/R-1984-02-0257
The Synthesis of C-13 Labeled Vitamin E, [8‘a-13C]all-rac-α-Tocopherol

Shiro Urano,* Kukimo Tokuzawa, Shun-ichiro Nakano, and Mitsuyoshi Matsuo

*Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-, Japan

Abstract

Vitamin E with a 13c-labeled isoprenoid side chain, [8‘a- 13C]all-rac-α-tocopherol (1), was synthesized using 6-methoxymethoxy- 2,5,7,8-tetramethyl-2-(5-mercaptothiazolinyl-4-methyl-3-penten-1-yl)chroman (8) as a key intermediate and [13C]methyl iodide as a 13C source. The total yield of the labeled tocopherol based on [13C]methyl iodide was 51.2%.