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Report | Regular issue | Vol 22, No. 1, 1984, pp.143-149
Published online, 1st January, 1970
DOI: 10.3987/R-1984-01-0143
Synthesis of the New Tricyclic System. Thieno[3’,2’:3,4]pyrido[1,2-a]pyrazin-4-one

Daniel Fréhel* and Jean-Pierre Maffrand

*Linge Hémobiologie, Sanofi Recherche, 195 route d‘Espagne, 31036 Toulouse, France


The new tricyclic system thieno[3’2’, : 3,4] pyrido(1,2-a)pyrazin-4-one, a thiophenic isostere of the heterocyclic system pyrazino(1,2-a)isoquinolin-4-one is synthesised by cyclisation in acidic medium from 4-acyl-6-hydroxy-1-[2-(2-thienyl)ethyl]piperazin-2-one. Those hydroxyimides result from selective reduction of corresponding piperazine-2,6-diones.