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Report | Regular issue | Vol 22, No. 1, 1984, pp.131-142
Published online, 1st January, 1970
DOI: 10.3987/R-1984-01-0131
Some 3-Carboxamides of β-Carboline and Tetrahydro-β-carboline

Ronald T. Coutts,* Ronald G. Micetich, Glen B. Baker, Abraham Benderly, Tim Dewhurst, Tse Wei Hall, Anthony R. Locock, and Jerry Pyrozko

*Faculty of Pharmacy , University of Alberta, Canada

Abstract

A series of tetrahydro-β-carboline-3-carboxamides (L- and D-series) was made by the interaction of the respective amine with the appropriate methyl tetrahydro-β-carboline-3-carboxylate. The β-carboline-3-carboxamides were prepared by a similar route from methyl β-carboline-3-carboxylate or by aromatization of the respective tetrahydro-β-carboline-3-carboxamide. The diastereomers of N-sec-butyl tetrahydro-β-carboline-3-carboxamide (L- and D-series) were separated by chromatography.