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Report | Regular issue | Vol 22, No. 1, 1984, pp.93-96
Published online, 1st January, 1970
DOI: 10.3987/R-1984-01-0093
Regioselective Cyanation of 3-Substituted Pyridine 1-Oxides

Wilmer K. Fife*

*Department of Chemistry, Indiana-Purdue University, PO Box 647, Indianapolis, IN 46223, U.S.A.

Abstract

Cyanstion of 3-X-pyridine 1-oxides with trimethylsilanecarbonitrile and dimethylcarbamoyl chloride occurs quantitatively to give 3-X-2-pyridinecarbonitriles ≥ 90% isolated yields when X = -CH3, -OCH3, -OH and -Cl, and approximately equal amounts of the 3- and 5- X derivatives when X = -CN and -COOCH3.