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Communication | Regular issue | Vol 22, No. 1, 1984, pp.43-47
Published online, 1st January, 1970
DOI: 10.3987/R-1984-01-0043
A Total Synthesis of (±)-Lysergene abd (±)-Agroclavine

Toshiko Kiguchi, Chiyomi Hashimoto, and Ichiya Ninomiya*

*Kobe Women’s College of Pharmacy, Motoyamakita, Higashinad, Kobe, Hyogo 658, Japan


A preliminary study on the exploitation of a general synthetic route to the ergoline group of alkaloids on the despyrrole analogs was successfully extended to the first total synthesis of racemic lysergene and agroclavine via the route involving reductive photocyclization of the furylenamide (10) followed by ring opening of the resulting dihydrofuran ring (11).