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Communication | Regular issue | Vol 20, No. 10, 1983, pp.1975-1978
Published online, 1st January, 1970
DOI: 10.3987/R-1983-10-1975
An Efficient Synthesis of (S)-(—)-Befunolol Hydrochloride Involving the Regioselective Condensation of (R)-Glycidol and 2-Acetyl-7-hydroxybenzofuran

Jun Nakano, Mitsuo Mimura, Mitsuo Hayashida, Kazuhiko Kimura, and Teruo Nakanishi

*Kaken Pharmaceutical Co., Ltd., Shinomiya, Minamikawara-cho, Yamashina-ku, Kyoto 607-8042, Japan


(S)-(—)-Befunolol·HCl (S)-(—)-(1) was synthesized via (S)-(+)-2-acetyl-7-(2,3-epoxypropoxy)benzofuran (5) which was prepared by redox dehydrative condensation of 2-acetyl-7-hydroxybenzofuran (3) and (R)-glycidol (4).