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Communication | Regular issue | Vol 20, No. 10, 1983, pp.1927-1932
Published online, 1st January, 1970
DOI: 10.3987/R-1983-10-1927
Pachygonamine and N-Methylpachygonamine, New Bisbenzylisoquinoline Alkaloids from Pachygone ovata

M. Uvais S. Sultanbawa, Subramaniam Sotheeswaran, Sinnathamby Balasubramaniam, Moustafa Abd El-Kawi, David J. Slatkin, and Paul L. Schiff, Jr.

*Department of Pharmacognosy, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A.

Abstract

Chromatography of methanolic extract of Pachygone ovata over silica gel afforded pachygonamine (1) and N-methylpachygonamine (2) which were characterized as new dibenzo-p-dioxin biphenyl bisbenzylisoquinoline alkaloids by a consideration of physicochemical data and conversion to N-methyltiliamosine (7). In addition, tiliamosine (3) was isolated for the first time from nature as the free base instead of the previously isolated N-acetylamide (4).