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Report | Regular issue | Vol 20, No. 9, 1983, pp.1805-1809
Published online, 1st January, 1970
DOI: 10.3987/R-1983-09-1805
Synthesis of 5-Fromyl-2,4,6-trisubstituted Pyrimidines

Thomas J. Delia and Ronald Otteman

*Department of Pharmacology, John Curtin School of Medical Research, Australian National University, GPOBox 334, Canberra, ACT 2601, Australia


A facile synthesis of 5-formyl-2,4,6-trisubstituted pyrimidines bearing amino and hydroxy groups is described. The Vilsmeier reagent, under mild conditions, gives good yields of products without accompanying chlorination of hydroxy groups.