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Report | Regular issue | Vol 20, No. 9, 1983, pp.1769-1772
Published online, 1st January, 1970
DOI: 10.3987/R-1983-09-1769
■ Facile Synthesis of 2-Amino-dihydro-4(1H)-pyrimidinone Derivatives: Cyclization of N-Substituted Guanidines with α,β-Unsaturated Esters

Yong Hae Kim and Nam Jin Lee

*Department of Chemistry, Korea Advanced Institute of Science and Technology, 373-1, Kusung-Dong, Yusung-Gu, Taejon, 305-701, Korea

Abstract

2-Amino-5,6-dihydropyrimidin-(1H)-4-one derivatives containing guanidine moiety (3) have been synthesized in excellent yields by the cyclization of free N-substituted guanidines with α,β-unsaturated esters such as methyl acrylate and methyl methacrylate derivatives under mild conditions.