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Report | Regular issue | Vol 20, No. 6, 1983, pp.1123-1126
Published online, 1st January, 1970
DOI: 10.3987/R-1983-06-1123
A New Versatile Synthesis of 4-Acyl-5-methyl-4-isoxazolin-3-ones

Soji Sugai, Kazuo Sato, Takashi Ueda, Kumiko Kataoka, and Kazuo Tomita

*Agroscience Research Laboratories, Sankyo Co., Ltd., 1041 Yasu, Yasu-cho, Yasu-gun, Shiga 520-2342, Japan


Treatment of N-substituted N-hydroxyacetoacetamides 1 with acyl chlorides in the presence of two equivalents of triethylamine gave 4-acyl-5-methyl-4-isoxazolin-3-ones 5. The reaction was thought to proceed via acyl rearrangement as shown in 8 and 9.