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Report | Regular issue | Vol 20, No. 6, 1983, pp.1099-1107
Published online, 1st January, 1970
DOI: 10.3987/R-1983-06-1099
Synthesis of 5-Oxoindolizine Derivatives. II: Reaction of Ethyl Pyrrolidin-2-ylideneacetate (an Enamine Ester) with Acyclic α,β-Unsaturated Carbonyl Compounds

Tatsuo Nagasaka, Hitoshi Inoue, and Fumiko Hamaguchi

*School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


Synthesis of some 5-oxoindolizine derivatives using ethyl pyrrolidin-2-ylideneacetate (1) and acyclic α,β-unsaturated carbonyl compounds is described. The structures of Michael adducts, intermediates for 5-oxoindolizines, obtained by treatment of with 1 dimethyl acetylenedicarboxylate or methyl propiolate are discussed.