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Communication | Regular issue | Vol 20, No. 6, 1983, pp.991-994
Published online, 1st January, 1970
DOI: 10.3987/R-1983-06-0991
Studies on Pyrimidine Derivatives. XXXI. Synthesis of Chloromethylpyrimidines by Reactin of Monomethylpyrimidine N-Oxides with Phosphoryl Chloride

Takao Sakamoto, Sohichi Kaneda, Yoshiaki Hama, Hiroshi Yoshizawa, and Hiroshi Yamanaka

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

The reaction of 2- and 6-methylpyrimidine 1-oxides with phosphoryl chloride underwent the selective side-chain chlorination to give 2- and 6-chloromethylpyrimidines as sole products. No by-products such as 2-chloro- and 4-chloropyrimidines were obtained even in the cases of the N-oxides having a free active position in the nucleus.