Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 20, No. 6, 1983, pp.991-994
Published online, 1st January, 1970
DOI: 10.3987/R-1983-06-0991
Studies on Pyrimidine Derivatives. XXXI. Synthesis of Chloromethylpyrimidines by Reactin of Monomethylpyrimidine N-Oxides with Phosphoryl Chloride

Takao Sakamoto, Sohichi Kaneda, Yoshiaki Hama, Hiroshi Yoshizawa, and Hiroshi Yamanaka

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


The reaction of 2- and 6-methylpyrimidine 1-oxides with phosphoryl chloride underwent the selective side-chain chlorination to give 2- and 6-chloromethylpyrimidines as sole products. No by-products such as 2-chloro- and 4-chloropyrimidines were obtained even in the cases of the N-oxides having a free active position in the nucleus.