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Report | Regular issue | Vol 20, No. 5, 1983, pp.817-828
Published online, 1st January, 1970
DOI: 10.3987/R-1983-05-0817
A Short Improved Synthesis of N-Substituted 5-Aza-2-oxa-3-oxo-bicyclo[2.2.1]heptanes

Margaret M. Bowers-Nemia and Madeleine M. Joullié

*Department of Chemistry, University of Pennsylvania, 231 South 34th Street Philadelphia, PA 19104-6323, U.S.A.


N-Substituted 5-aza-2-oxa-3-oxo-bicyclo[2.2.1]heptanes are conformationally rigid models that have been used in several 1H-NMR studies. They have previously been obtained by multistep processes. We have devised a one step synthesis for these compounds. The utility of this new route has been demonstrated for five differently N-substituted substrates.