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Communication | Regular issue | Vol 20, No. 5, 1983, pp.749-752
Published online, 1st January, 1970
DOI: 10.3987/R-1983-05-0749
Pyrimido[1,2-b]-1,2,4-triazolo[4,3-f]pyridazine, a Novel Ring System

Judit Kosáry, Endre Kasztreiner, and Márta Sóti

*Institute for Drug Research Ltd., H-1325 Budapest, POB 82, Hungary


The novel ring system pyrimido[1,2-b]-1,2,4-triazolo-[4,3-f]pyridazine was prepared either by ring closure of 6-(3-hydroxypropylamino)-1,2,4-triazolo[4,3-b]pyridazine 2a in polyphosphoric acid and the hydrazone 7 with bromine. Compound 1 showed a positive inotropic effect.