Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 20, No. 2, 1983, pp.205-211
Published online, 1st January, 1970
DOI: 10.3987/R-1983-02-0205
1-(3-Diazo-2-oxopropyl)-4-thio-substituted Azetidine-2-ones. Versatile Intermediates for the Preparation of Bicyclic β-Lactams: Synthesis of Novel Cephem Derivatives

Hans Fliri, Ching-Pong Mak, Kapa Prasad, Gerhard Schulz, and Peter Stütz

*Sandoz Forschungsinstitut, 1235 Wien, Brunnerstraße 59, Austria

Abstract

Metal-catalyzed thermal decomposition of diazoketones 3c-3f afforded different substituted cephems, whose formation can be rationalized by assuming different reaction pathways. Possible mechanisms are proposed, and the effect of various 4-thio-substituents on the decomposition of these diazoketones are summarised.