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Report | Regular issue | Vol 20, No. 1, 1983, pp.51-54
Published online, 1st January, 1970
DOI: 10.3987/R-1983-01-0051
Rearrangement and Alkylation of Some 1,2,4-Triazine Derivatives

Said A. El-Bahaie, Mohamed A. Badawy, Sayed A. Abdel-Hady, and Yehia A. Ibrahim

*Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt

Abstract

4-Aryl-5-oxo-3-alkylmercapto-1,2,4-triazine derivatives undergo interesting reaction with ammonia to give mainly, instead of the expected corresponding 3-amino derivatives, the 3-arylamino-2,5-dihydro-5-oxo-1,2,4-triazines. In this reaction 4-aryl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazines were obtained as a minor product. Alkylation of 3-arylamino-4,5-dihydro-5-oxo-1,2,4-triazines with methyl iodide in alkaline medium gives the corresponding 2-methyl derivatives. Independent synthesis of 2- and 4-methyl-3-arylamino-1,2,4-triazine derivatives is alao described.