Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 20, No. 1, 1983, pp.5-8
Published online, 1st January, 1970
DOI: 10.3987/R-1983-01-0005
7α-Methoxylation of Cephalosporins

Katsuyoshi Iwamatsu, Koichi Shudo, and Toshihiko Okamoto

*Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan


A method for 7α-methoxylation of cephalosporins is described. Treatment of the imidoyl chlorides of cephalosporins (2) with 4-methoxypyridine N-oxide afforded (4-pyrido-1-yl)oxyimino compounds (3), which were transformed to 7α-methoxycephalosporins (4) via thermal 1,4-elimination followed by addition of methanol.