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Communication | Regular issue | Vol 19, No. 12, 1982, pp.2309-2312
Published online, 1st January, 1970
DOI: 10.3987/R-1982-12-2309
Double Ring-transformation of Uracils to Pyrazolones via Hydantoin Ring System

Kosaku Hirota, Yoshihiro Yamada, Jun-ichi Haruta, and Shigeo Senda

*Labolatory of Medicinal Chemistry, Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan

Abstract

Hydrazinolysis of 3-alkyl-1-aryl-5-bromo-6-methyluracil derivatives (1) causes a novel double ring-transformation to pyrazolones (2) via hydantoin ring system.