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Communication | Regular issue | Vol 19, No. 12, 1982, pp.2283-2286
Published online, 1st January, 1970
DOI: 10.3987/R-1982-12-2283
An Improved Conversion of 1,4,6-Trisubatituted 2(1H)-Pyrimidinones into the Corresponding Thiones

Akira Katoh, Choji Kashima, and Yoshimori Omote

*Department of Chemistry, University of Tsukubaa, 1-1-1 Ten-nodai, Tsukuba-shi, Ibaraki, 305-8571, Japan


1,4,6-Trisubstituted 2(1H)-pyrimidinones (2a-j) are easily converted into the corresponding thiones (3a-j) in high yields by reacting with 2,4-bis(p-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (1). Further, other diazines, e.g., 2-methyl-6-phenyl-3(2H)-pyridazinone (4) and 1-methyl-5,6-diphenyl-2(1H)-pyrazinone (6) are also converted into the corresponding thiones 5 and 7 in 99 and 91% yield, respectively.