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Communication | Regular issue | Vol 19, No. 12, 1982, pp.2251-2254
Published online, 1st January, 1970
DOI: 10.3987/R-1982-12-2251
Activated Nitriles in Heterocyclic Synthesis: A Novel Synthesis of Pyrazolo[5,6:3’,4’]pyrano[5,4-b]isoxazoles

Suzan Ibraheim Aziz, Bahia Yahia Riad, Hassan Attia Elfahham, and Mohamed Hilmy Elnagdi

*Chemistry Department, Faculty of Science, Minia University, Minia, Egypt

Abstract

A novel synthesis of pyrano[2,3-c]isoxazoles is reported via reaction of 4-arylidene-2-isoxazolin-5-ones with malononitrile and ethyl cyanoacetate. The synthesised isoxazole derivatives were converted into derivatives of new ring system pyrazolo[5,6:3’,4’]pyrano[5,4-b]isoxazole via reaction with hydrazine hydrate.