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Report | Regular issue | Vol 19, No. 11, 1982, pp.2151-2154
Published online, 1st January, 1970
DOI: 10.3987/R-1982-11-2151
Base-catalyzed Racemization of Nicotine

Yasuko Tsujino, Saizo Shibata, Akio Katsuyama, Takuro Kisaki, and Hajime Kaneko

*Central Reseasrch Institute, Japan Tobacco Inc., 6-2, Umegaoka, Midori-ku, Yokohama, Kanagawa 227-8512, Japan


Catalytic activities of various bases on the racemization of nicotine were investigated. S-(—)-Nicotine was completely racemized by refluxing with a catalytic amount of potassium-t-butoxide for a short time. Thus, a facile preparation method of racemic nicotine was provided.