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Report | Regular issue | Vol 19, No. 10, 1982, pp.1931-1934
Published online, 1st January, 1970
DOI: 10.3987/R-1982-10-1931
(—)-4α-Hydroxysparteine, a New Natural Product from Acosmium panamense

Manuel F. Balandrin and A. Douglas Kinghorn

*Department of Pharmacognosy and Pharmacology, College of Pharmacy, University of Illinois at the Medical Center, Chicago, IL 60612, U.S.A.

Abstract

(-)-1-4α-Hydroxysparteine (1) was obtained for the first time as a natural product from a methanol extract of the bark of Acosmium panamense (Leguminosae). The structure and stereochemistry of 1 were confirmed by gc/ms comparison of the acetylated product of 1 with authentic samples of 4α-acetoxysparteine (2) and 4β-acetoxysparteine (6). 4α-Hydroxysparteine , (1) and 2,4-d2-4α-hydroxysparteine (7) were prepared by reduction of multi-florine (3) with sodium borohydride and sodium borodeuteride in methanol, respectively.