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Report | Regular issue | Vol 19, No. 10, 1982, pp.1879-1882
Published online, 1st January, 1970
DOI: 10.3987/R-1982-10-1879
The Reaction of 2,4-Dichloroquinazoline with N-Alkylpyrrolidines

Hideki Miki and Fumiko Kasahara

*Central Research Division, Takeda Chemical Industries, Ltd., 17-85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan

Abstract

The reaction of 2,4-dichloroquinazoline with N-methylpyrrolidine gave N-(2-chloro-4-quinazolinyl)-N-methylpyrrolidinium chloride, which was heated to give 2-chloro-4-(N-methyl-4-chloro- butylamino)quinazoline and reacted also with water in the presence of excess N-methylpyrrolidine to give a stable zwitter ion, 4-(N- methylpyrrolidino)-2-quinazolinolate.