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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Communication | Regular issue | Vol 19, No. 10, 1982, pp.1797-1800
Published online, 1st January, 1970■ Synthesis of 7-Hydroxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-6-carboxylic Acids and 4-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acids
Published online, 1st January, 1970
DOI: 10.3987/R-1982-10-1797
■ Synthesis of 7-Hydroxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-6-carboxylic Acids and 4-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acids
Régine Sola, Daniel Frehel, Jean-Pierre Maffrand, and Jean Brugidou
*Sanofi Recherche, Linge Hèmobiologie, 195, route d’Espagne, 31024 Toulouse, France
Abstract
This paper deals with the synthesis of 7-hydroxy-4,5,6,7-tetrahydrothieno[3,2-c] pyridine-6- and 4-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids by Pictet-Spengler cyclisation of the corresponding β-thienylserines and β-phenylserines respectively. Their diastereoisomers were separated and identified.
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