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Communication | Regular issue | Vol 19, No. 10, 1982, pp.1797-1800
Published online, 1st January, 1970
DOI: 10.3987/R-1982-10-1797
Synthesis of 7-Hydroxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-6-carboxylic Acids and 4-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acids

Régine Sola, Daniel Frehel, Jean-Pierre Maffrand, and Jean Brugidou

*Sanofi Recherche, Linge Hèmobiologie, 195, route d’Espagne, 31024 Toulouse, France


This paper deals with the synthesis of 7-hydroxy-4,5,6,7-tetrahydrothieno[3,2-c] pyridine-6- and 4-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids by Pictet-Spengler cyclisation of the corresponding β-thienylserines and β-phenylserines respectively. Their diastereoisomers were separated and identified.