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Communication | Regular issue | Vol 19, No. 8, 1982, pp.1431-1433
Published online, 1st January, 1970
DOI: 10.3987/R-1982-08-1431
Total Synthesis of (±)-Corynoline and (±)-6-Oxocorynoline

Mark Cushman and Yash Pal Gupta

*Department of Medicinal Chemistry and Molecular Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, 1333 Robert E. Heine Pharmacy Building, West Lafayette IN 47907, U.S.A.


The condensation of α-methyl-3,4-methylenedioxyhomophthalic anhydride (7) with piperonylidenemethylamine (8) is utilized as the key step in a total synthesis of (±)-corynoline (1) and (±)-6-oxocorynoline (2).