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Communication | Regular issue | Vol 19, No. 7, 1982, pp.1211-1214
Published online, 1st January, 1970
DOI: 10.3987/R-1982-07-1211
The Preparation of α,β-Unsaturated Ketones by the Grignard Reaction with β-(N-Alkyl-N-acylamino)enones

Choji Kashima and Yasuhiro Yamamoto

*Department of Chemistry, University of Tsukubaa, 1-1-1 Ten-nodai, Tsukuba-shi, Ibaraki, 305-8571, Japan


The Grignard reaction of β-(N-alkyl-N-acylamino)enones afforded regioselectively α,β-unsaturated β-(N-alkyl-N-acylamino)alcohols, which were converted into α,β-unsaturated ketones by hydrolysis accompanying dehydration. The resulting α,β-unsaturated ketones were regioisomeric with α,β-unsaturated ketones derived from β-(N,N-dialkylamino)enones by the Grignard reaction.