Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 19, No. 6, 1982, pp.1013-1017
Published online, 1st January, 1970
DOI: 10.3987/R-1982-06-1013
Synthesis of 3,3,5-Trimethoxy-2-pyrrolidinone and Its Derivatives

Yoshiyuki Kosugi, Fumiko Hamaguchi, Tatsuo Nagasaka, Sadao Ohki, and Hiroyuki Kikuchi

*School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


A convenient synthesis of 3,3,5-trimethoxy-2-pyrrolidinone (11a-c) by using a reaction of α-halo-β-formylacrylic acid [3-halo-5-hydroxy-2(5H)-furanone] (3a-d) with alkoxide is described. An investigation for synthesis of 2,3-pyrrolidinediones is also mentioned.