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Communication | Regular issue | Vol 19, No. 6, 1982, pp.1013-1017
Published online, 1st January, 1970
DOI: 10.3987/R-1982-06-1013
Synthesis of 3,3,5-Trimethoxy-2-pyrrolidinone and Its Derivatives

Yoshiyuki Kosugi, Fumiko Hamaguchi, Tatsuo Nagasaka, Sadao Ohki, and Hiroyuki Kikuchi

*School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

A convenient synthesis of 3,3,5-trimethoxy-2-pyrrolidinone (11a-c) by using a reaction of α-halo-β-formylacrylic acid [3-halo-5-hydroxy-2(5H)-furanone] (3a-d) with alkoxide is described. An investigation for synthesis of 2,3-pyrrolidinediones is also mentioned.