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Communication | Regular issue | Vol 19, No. 6, 1982, pp.1003-1007
Published online, 1st January, 1970
DOI: 10.3987/R-1982-06-1003
Biomimetic Approach to Potential Benzodiazepine Agonists and Antagonists

Michael Cain, Fil Guzman, James M. Cook, Kenner C. Rice, and Phil Skolnick

*Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, U.S.A.


A series of heterocycles have been prepared via the Pictet-Spengler reaction and several of these (β-carbolines 2-8, isoquinoline 11a and imidazopyridine derivative 16b) have been found to bind to the benzodiazepine receptor in vitro with moderate to high affinity.