Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Report | Regular issue | Vol 19, No. 5, 1982, pp.857-860
Published online, 1st January, 1970
DOI: 10.3987/R-1982-05-0857
Syntheses of (—)-9-Dimethylcephaeline and (—)-10-Demethylcephaeline

Tozo Fujii and Masashi Ohba

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


The synthesis of (—)-9-demethylcephaeline (I) has been accomplished by reduction of (+)-O,O-dibenzyl-9-demethylpsychotrine (Xla) followed by debenzylation of the resulting (—)-tetrahydroisoquinoline derivative XIIa. A parallel synthesis starting with (+)-O,O-dibenzyl-10-demethylpsychotrine (Xlb), prepared from the (—)-tricyclic amino ester Vlllb through the (—)-amino acid IXb and the (—)-amide Xb, gave (—)-10-demethylcephaeline (II).