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Report | Regular issue | Vol 19, No. 4, 1982, pp.691-695
Published online, 1st January, 1970■ Synthesis of Weberine and Norweberine and Their 1-Methyl Congeners
Published online, 1st January, 1970
DOI: 10.3987/R-1982-04-0691
■ Synthesis of Weberine and Norweberine and Their 1-Methyl Congeners
Kimio Takahashi and Arnold Brossi
*Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestve and Kidney Diseases, National Institute of Health, Bethesda, MD 20892-0820, U.S.A.
Abstract
The synthesis of 2-methyl-5,6,7,8-tetramethoxy-1,2,3,4-tetrahydroisoquinoline (weberine) 5 from 2,3,4,5-tetramethoxy-β-phenylethylamine via norweberine 4 is described. The synthesis of their 1-methyl homologs was also accomplished.
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