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Communication | Regular issue | Vol 19, No. 4, 1982, pp.641-646
Published online, 1st January, 1970
DOI: 10.3987/R-1982-04-0641
On Cardioactive Steroids VI. The Synthesis of 17α-Methyl Cardenolides

Karnail S. Atwal, Soumya P. Sahoo, Thomas Y. R. Tsai, and Karel Wiesner

*Natural Products Research Center, Department of Chemistry, University of New Brunswick, Bag Service #45222, Fredericton, New Brunswick, E3b 5A3, Canada


Two methods for the simple synthesis of the Δ14,15-17α-methyl cardenolide 1 are disclosed. This material may be functionalized to a variety of 17α-methyl derivatives for pharmacological testing. As an example, the preparation of 17α-methyl digitoxigenin 20 is described.