Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 19, No. 3, 1982, pp.521-524
Published online, 1st January, 1970
DOI: 10.3987/R-1982-03-0521
Meldrum’s Acid in Organic Synthesis 4. Synthesis of 5-Substituted 2-Phenylisoxazolin-3-one from N-Acylacetylphenylhydroxylamines

Kunihiko Mohri, Yuji Oikawa, Ken-ichi Hirao, and Osamu Yonemitsu

*Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan


When N-acylacetylphenylhydroxylamines, readily prepared from phenylhydroxylamine and acyl Meldrum’s acids (5-acyl-2,2-dimethyl-1,3-dioxane-4,6-diones) were refluxed in benzene in the presence of a catalytic amount of p-toluenesulfonic acid, an acid-catalyzed dehydrative cyclization occurred smoothly to afford 5-substituted 2-phenylisoxazolin-3-ones in high yields.