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Communication | Regular issue | Vol 19, No. 3, 1982, pp.507-509
Published online, 1st January, 1970
DOI: 10.3987/R-1982-03-0507
Synthesis of Dutadrupine

François Tillequin, Geneviève Baudouin, and Michel Koch

*Laboratoire de Pharmacognosie, URA au CNRS n1310, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, 4, Avenue de l’Observatoire, F-75006 Paris, France


Dutadrupine (3) was synthetized by Claisen rearrangement of 7-(1,1-dimethylpropyn-1-oxy)-4-methoxyfuro[2,3b]quinoline (2) obtained by condensation of 7-hydroxy-4-methoxyfuro[2,3b]quinoline (1) with 3-chloro-3-methylbutyne.