Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Report | Regular issue | Vol 19, No. 2, 1982, pp.305-311
Published online, 1st January, 1970
DOI: 10.3987/R-1982-02-0305
Synthesis of Heterocyclic Compounds. XXII. Preparation of 6-Aryl-2-thioxopyrimidines

José L. García Navío, Antonio Lorente, and José L. Soto

*Departamento de Química Orgánica, Universidad de Alcalá de Henares, 28871 Alcalá de Henares (Madrid), Spain


The reactions of different ethyl benzylidenecyanoacetates (I) and benzylidenemalononitriles (V) with thiourea in an alcohol-alkoxide medium, provide a new and simple method for the synthesis of 6-aryl-5-cyano-4-oxo-2-thioxohexahydropyrimidines (III) and 4-amino-6-aryl-5-cyano-2-thioxotetrahydropyrimidines (VI), respectively. Similarly, the reaction of ethyl benzylidenemalonate leads to 5-ethoxycarbonyl-4-oxo-6-phenyl-2-thioxohexahydropyrimidine (XI).