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Communication | Regular issue | Vol 19, No. 2, 1982, pp.235-239
Published online, 1st January, 1970
DOI: 10.3987/R-1982-02-0235
The Facile Addition od Secondary Amines to Withaferin A. A Further Example of Alumina-Catalyzed Addition of Amines to α,β-Unsaturated Ketones

S. William Pelletier, Gulilat Gebeyehu, and Naresh V. Mody

*Department of Chemistry, Institute for Natural Products Research, The University of Georgia, Chemistry Building, Athens, Georgia 30602-2556, U.S.A.

Abstract

The alumina-catalyzed addition of various secondary amines to withaferin A (1) is facile and efficient. The addition is illustrated by the preparation in excellent yield of 3-aziridinyl-2,3-dihydrowithaferin A (2), a compound with significant in vivo antitumor activity.