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Communication | Regular issue | Vol 19, No. 1, 1982, pp.49-51
Published online, 1st January, 1970
DOI: 10.3987/R-1982-01-0049
Synthesis of Pyrido[2,1-a]isoindol-6(2H)-one and Its Analogs

Yohshihito Abe, Akio Ohsawa, and Hiroshi Igeta

*School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan


Treatment of o-(2-pyridyl)benzaldiacetate (1a) with HCI afforded pyrido[2,1-a]isoindol-6(2H)-one (3a). 6-Hydroxypyrido[2,1-a]isoindolium hydrochloride (5) was suggested to be an intermediate. Isoindolo[2,1-a]quinolin-11(5H)-one (3b) and isoindolo[l,2-a]isoquinolin-8(12bH)-one (3c) were obtained in a similar way. Enol isomers (e.g. 7) of 3a-c were not detected by 1HNMR and 13CNMR spectrum.