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Communication | Regular issue | Vol 19, No. 1, 1982, pp.23-25
Published online, 1st January, 1970
DOI: 10.3987/R-1982-01-0023
A Synthesis of (+)-2-Oxa-6-azabicyclo[3.3.0]octan-3-one (The Geissman-Waiss Lactone): A Synthon for Some Necines

Heinrich Rüeger and Michael Benn

*Department of Chemistry, The University of Alberta, Calgary, Alberta, T2N, 1N4, Canada


The lactone (1), an intermediate in the Geissman-Waiss synthesis of retronecine and a potential synthon for other necines, was synthesised from 4-hydroxy-L-proline.