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Communication | Regular issue | Vol 19, No. 1, 1982, pp.15-18
Published online, 1st January, 1970
DOI: 10.3987/R-1982-01-0015
Formation Mechanism of 2-(N-Alkyl-4-chlorobutylamino)-4-chloroquinazoline

Hideki Miki

*Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan


The reaction of 2,4(1H,3H)-quinazolinedione (1) with N-alkylpyrrolidine in phosphoryl chloride undergoes readily the reaction of a von Braun type through the formation of dichlorophosphate and a quaternary ammonium salt in sequence, which decomposes to give 2-(N-alkyl-4-chlorobutylamino)-4-chloroquinazoline (3). A conceivable reaction mechanism is discussed.