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Communication | Regular issue | Vol 16, No. 12, 1981, pp.2149-2154
Published online, 1st January, 1970
DOI: 10.3987/R-1981-12-2149
Reactions of 4-Ethoxyalkylidene-2-phenyl-2-oxazolin-5-ones with 1,3-Binucleophilic Heteroaromatic Systems

Otohiko Tsuge* and Michihiko Noguchi

*Research Institute of Industrial Science, Faculty of Engineering, Kyushu University, 6-1, Kasuga-koen, Kasuga 816-8580, Japan


One-pot syntheses of pyrido[1,2-b]pyrimidine and thiazolo[2,3-b]pyrimidine derivatives were achieved by the reactions of 4-ethoxyalkylidene-2-phenyl-2-oxazolin-5-ones with 2-aminopyridines and 2-aminothiazole in refluxing ethanol, respectively. In the reaction of the oxazolinone with 2-aminopyrimidine under similar conditions, however, the expected pyrimidopyrimidine derivative was not formed, but instead (2-pyrimidylaminomethylene)-oxazolinone and its ethanolysis product were obtained.