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Communication | Regular issue | Vol 16, No. 12, 1981, pp.2141-2148
Published online, 1st January, 1970
DOI: 10.3987/R-1981-12-2141
Structure of Sanggenon C, a Natural Hypotensive Diels-Alder Adduct from Chinese Crude Drug “Sang-bái-pí” (Morus Root Bark)

Taro Nomura,* Toshio Fukai, Yoshio Hano, and Jun Uzawa

*School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

From the methanol extract of the Chinese crude drug “sang-Bái-Pí” (Japanese name Sohakuhi), the root barks of Morus sp. (Moraceae), a new flavanone derivative with a fused dihydrochalcone partial moiety was isolated and named sanggenon C. The structure was shown to be I on the basis of chemical and spectral data. Sanggenon C (I) is regarded biogenetically as a Diels-Alder adduct of a chalcone derivative and a dehydroprenylflavanone derivative. Intravenous injection of I (1 mg/Kg) produced a significant hypotension in rabbit.