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Communication | Regular issue | Vol 16, No. 12, 1981, pp.2137-2140
Published online, 1st January, 1970
DOI: 10.3987/R-1981-12-2137
A Novel Synthesis of Theophyline Derivatives

Fumio Yoneda* and Ryosuke Koga

*Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-hon-machi, Kumamoto 862-0973, Japan


Treatment of 6-amino-5-arylazo-1,3-dimethyluracils with ethyl propiolate gave the corresponding Michael-type adducts, 6-ethoxycarbonylvinylaminouracils, which on treatment with a mixture of hydrochloric acid and acetic acid gave rise to 8-anilinomethyltheophylline derivatives.