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Report | Regular issue | Vol 16, No. 9, 1981, pp.1583-1585
Published online, 1st January, 1970
DOI: 10.3987/R-1981-09-1583
A Short Synthesis of 3-Oxo-1,2,3,4,5,6,7,8-octahydroisoquinoline-1-spiro-1’-cyclohexane

Kai S. Ng, Richard E. S. Sutcliffe, Peter S. Rutledge,* and Paul D. Woodgate

*Department of Chemistry, University of Auckland, Private Bag 92019, Auckland, New Zealand


Equimolar amounts of cyclohexanone and 1-cyclohexenylacetonitrile in polyphosphoric acid give 3-oxo-1,2,3,4,5,6,7,8-octahydroisoquinoline-1-spiro-1’-cyclohexane (4).