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Report | Regular issue | Vol 16, No. 9, 1981, pp.1573-1578
Published online, 1st January, 1970
DOI: 10.3987/R-1981-09-1573
α,β-Unsaturated Carboxylic Acid Derivatives. 20. N-Methylation of α-Dehydroamino Acid Ester and Its Cyclic Dipeptide from Various Routes

Chung-gi Shin,* Yoshiaki Sato, Masato Hayakawa, Masamichi Kondo, and Juji Yoshimura

*Departmnet of Applied Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan

Abstract

The selective N-methylation of 1-, 4-, and 1,4-positions of individual 3- and 3,6-dialkylidene-2,5-piperazinediones (PDO) either by the cyclization of α-dehydroamino acid ester with methylamine or by the reaction of PDO with methyl iodide in the presence of sodium hydride was performed to give the desired product in a fairly good yield.