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Communication | Regular issue | Vol 16, No. 8, 1981, pp.1315-1319
Published online, 1st January, 1970
DOI: 10.3987/R-1981-08-1315
Synthesis of 2-Formyladenosine Using Diethoxyacetonitrile as a Synthon

Teiichi Murakami, Masami Otsuka, Susumu Kobayashi, and Masaji Ohno*

*Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan


Diethoxyacetonitrile has been utilized for the effective synthesis of adenine derivatives as a synthon. Novel 2-formyladenine (2b) and 2-formyladenosine (5b) have been prepared in high yields starting from AICN (1) and AICNR (4b), respectively.